Download MASTER EN ONCOLOGÍA MOLECULAR El gen p53: estructura y
Document related concepts
Transcript
MASTER EN ONCOLOGÍA MOLECULAR El gen p53: estructura y actividad biológica. La ruta p53-Mdm2-ARF. p53: mutaciones y sus efectos. BIBLIOGRAFÍA Revisiones generales de p53 Aylon Y, Oren M. (2007) Living with p53, dying of p53. Cell, 130, 597-600. Murray-Zmijewski F, Slee EA, Lu X. (2008) A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol, 9, 702-12. Junttila MR, Evan GI (2009) p53, a Jack of all trades but master of none. Nat Rev Cancer, 9, 821-9. Brady CA, Attardi LD. (2011) p53 at a glance. Journal of Cell Science, 123, 2527-2532 Funciones no-canónicas de p53 Vousden KH, Lane DP. (2007) p53 in health and disease. Nat Rev Mol Cell Biol, 8, 275-83. Rodier F, Campisi J, Bhaumik D. (2007) Two faces of p53: aging and tumor suppression. Nucleic Acids Res, 35, 7475-84. Vousden, K. H. and Ryan, K. M. (2009) p53 and metabolism. Nat. Rev. Cancer 9, 691-700. Alteraciones de p53 en tumores Vousden KH, Prives C. (2005) p53 and prognosis: new insights and further complexity. Cell, 120, 7-10. Soussi T (2007) p53 alterations in human cancer: more questions than ans wers. Oncogene, 26, 2145-56 Goh AM, Coffill CR, Lane DP. (2011) The role of mutant p53 in human cancer. J Pathol., 223,116-26. La familia de p53 Olivares-Illana V, Fåhraeus R (2010) p53 isoforms gain functions. Oncogene, 29, 5113-9. Machado-Silva A, Perrier S, Bourdon JC (2010) p53 family members in cancer diagnosis and treatment. Semin Cancer Biol., 20:57-62. p53 como diana terapeutica Shangary S, Wang S. (2008) Targeting the MDM2-p53 interaction for cancer therapy. Clin Cancer Res, 14, 5318-24 Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP (2009) A wakening guardian angels: drugging the p53 pathway. Nat Rev Cancer, 9, 862-73.