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GuÃas para el diagnóstico y tratamiento de la Insuficiencia CardÃaca secondary mitral regurgitation in end-stage cardiomyopathy with mitral annuloplasty. Am J Cardiol 1996;78:966-9. 31. CONNOLLY HM, OH JK, ORSZULAK TA, et al. Aortic valve replacement for aortic stenosis with severe left ventricular dysfunction: prognostic indicators. Circulation 1997;95:2395-400. 32. BOLLING SF, PAGANI FD, DEEB GM, BACH DS. Intermediateterm outcome of mitral reconstruction in cardiomyopathy. J Thorac Cardiovasc Surg 1998;115:381-6. 33. EVANGELISTA A, TORNOS P, SAMBOLA A, PERMANYERMIRALDA G, SOLER-SOLER J. Long-term vasodilator therapy in patients with severe aortic regurgitation. N Engl J Med 2005;353:1342â9 Tratamiento Pacientes en Estadio C. 1. GOOD CB, MCDERMOTT L, MCCLOSKEY B. Diet and serum potassium in patients on ACE-inhibitors. JAMA 1995;274:538. 2. Working Group on Cardiac Rehabilitation and Exercise Physiology and Working group on Heart Failure of the European Society of Cardiology. Recommendations for exercise testing in CHF patients. Eur Heart J 2001;22:37â45. 3. The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991;325:293-302. 4. COHN JN, JOHNSON G, ZIESCHE S, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1991;325:303-10. 5. The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987;316:1429-35. 6. PACKER M, POOLE-WILSON PA, ARMSTRONG PW et al. Comparative effects of low and high doses of the angiotensinconverting enzyme inhibitor, lisinopril, on morbidity and mortality in CHF. ATLAS Study Group. Circulation 1999;100:2312â2318. 7. PITT B, POOLE-WILSON PA, SEGAL R et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomized trialâthe Losartan Heart Failure Survival Study ELITE II. Lancet 2000;355:1582â1587. 8. COHN JN, TOGNONI G. Arandomized trial of the angiotensinreceptor blocker valsartan in chronic heart failure. N Engl J Med 2001;345:1667-75. 9. GRANGER CB, MCMURRAY JJ, YUSUF S, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensinconverting-enzyme inhibitors: the CHARM-Alternative trial. Lancet 2003;362:772-6. 10. VALIANT. N Engl J Med 2003;349:1893-906 11. MCMURRAY JJ, OSTERGREN J, SWEDBERG K et al. Effects of candesartan in patients with CHF and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM Added trial. Lancet 2003;362:767â771. 12. PACKER M, BRISTOW MR, COHN JN et al. The effect of carvedilol on morbidity and mortality in patients with CHF. US Carvedilol Heart Failure Study Group. N Engl J Med 1996;334: 1349â1355. 13. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomized trial. Lancet 1999;353:9 14. (MERIT-HF). Effect of metoprolol CR/XL in CHF: Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure. Lancet 1999;353:2001â2007. 15. MARCUS D. FLATHER, MARCELO C. SHIBATA, ANDREW J.S. COATS, DIRK J. VAN VELDHUISEN, et.al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS) European Heart Journal (2005) 26, 215â225. 16. RONNIE WILLENHEIMER, DIRK J. VAN VELDHUISEN, BERNARD SILKE, ERLAND ERDMANN, FERENC FOLLATH, et al on behalf of the CIBIS III Investigators. Effect on Survival and Hospitalization of Initiating Treatment for Chronic Heart Failure With Bisoprolol Followed by Enalapril, as Compared With the Opposite Sequence: Results of the Randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III Circulation 2005 112: 2426-2435 17. PITT B, ZANNAD F, REMME WJ, et al, for the Randomized Aldactone Evaluation Study Investigators. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999;341:709-17. 18. PITT B, WILLIAMS G, REMME W, et al. The EPHESUS trial eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction: Eplerenone Post- AMI Heart Failure Efficacy and Survival Study. Cardiovasc Drugs Ther 2001;15:79-87. 19. The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 1997;336:525-33. 20. COHN JN, ARCHIBALD DG, ZIESCHE S, et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure: results of a Veterans Administration Cooperative Study. N Engl J Med 1986;314:1547-52. 21. LOEB HS, JOHNSON G, HENRICK A, et al, for the V-HeFT VA Cooperative Studies Group. Effect of enalapril, hydralazine plus isosorbide dinitrate, and prazosin on hospitalization in patients with chronic congestive heart failure. Circulation 1993;87: 22. TAYLOR AL, ZIESCHE S, YANCY C et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 2004;351:2049â2057. Tratamiento Pacientes en Estadio D. 1. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult Circulation 2005:112;154-235 2. Guidelin es for the diagnosis and treatment of chronic heart failure full text (update 2005) Swedberg et al. Eur Heart Journal. h t t p : / / w w w. e s c a r d i o . o r g / k n o w l e d g e / g u i d e l i n e s / Chronic_Heart_Failure.htm?escid=271120 3. STEVENSON L. Tailored therapy before transplantation for treatment of advance heart failure: effective use of vasodilators and diuretics. J heart lung transplant 91; 10:468 4. CRESPO M. Tratamiento de la insuficiencia cardiaca refractaria o avanzada. Rev Esp Cardiol 2004; 57(9):869-83 5. The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987;316:1429-35. Revista Chilena de CardiologÃa - Vol. 26 Nº4, 2007 501