Download Diapositiva 1

UNIVERSIDAD DEL VALLE DE MÉXICO
DIVISIÓN DE CIENCIAS DE LA SALUD
Matriz Extracelular
DR. GERARDO CANCINO BALCÁZAR
Matriz extracelular
Matriz extracelular
Tejido Conectivo
Tejido Conectivo
Matriz extracelular
Matriz extracelular
Cornea de rata
Glucosaminoglucanos
Glucosaminoglucanos
Hialurona
Hialurona
Proteoglicanos
Proteoglicanos
Proteoglicanos
Quimiocinas e inflamación
Proteoglicanos
Proteoglicanos
Cartílago de rata
Proteoglicanos
PROTEOGLYCAN
APPROXIMATE
TYPE OF GAG CHAINS NUMBER OF GAG
MOLECULAR WEIGHT
CHAINS
OF CORE PROTEIN
Aggrecan
210,000
chondroitin sulfate +
keratan sulfate
~130
Betaglycan
36,000
1
Decorin
40,000
chondroitin sulfate/
dermatan sulfate
chondroitin sulfate/
dermatan sulfate
Perlecan
600,000
heparan sulfate
2–15
Syndecan-1
32,000
chondroitin sulfate +
heparan sulfate
1–3
Dally (in Drosophila)
60,000
heparan sulfate
1–3
1
LOCATION
FUNCTIONS
cartilage
mechanical support;
forms large
aggregates with
hyaluronan
binds TGF-β
cell surface and
matrix
widespread in
connective tissues
binds to type I
collagen fibrils and
TGF-β
basal laminae
structural and
filtering function in
basal lamina
epithelial cell surface cell adhesion; binds
FGF and other growth
factors
cell surface
co-receptor for
Wingless and
Decapentaplegic
signaling proteins
Colagena
Colagena
Migración de fibroblastos en colagena
Elastina
Elastina
Aorta de perro
Elastina
Fibronectina
Fibronectina
Actina regula el ensamble de fibras de
fibronectina
Fibronectina
Actina
Lamina Basal
Lamina Basal
Lamina Basal
Cornea de embrión de
pollo
ECM media la migración celular
ECM media la migración celular
Metaloproteasas