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SAN-ISN Course “State-of-the-art methods in Neuroscience Research” ROOM TOPACIO PROGRAM Day 1: 27/09/2015 18:00-19:00 Registration 19:15-19:30 Welcome words by course organizers 19:30-21:00 Lecture I: “Mapping neuronal networks with viral tools” María Soledad Espósito, Friedrich Miescher Institute, Basel, Switzerland 21:00 Dinner Day 2: 28/09/2015 09:00-10:30 Lecture II: “In vivo 2-photon microscopy for dissection of neuronal circuits” Johannes Letzkus, Max Planck Institute for Brain Research, Frankfurt, Germany 10:30-11:00 Coffee Break 11:00-12:30 Lecture III: “Visualizing large-scale neural ensemble dynamics in freely behaving mice" Mark Schnitzer, Stanford School of Medicine, Howard Hughes Medical Institute, USA 12:30 -13:30 Lunch 14:00-15:30 Session A: Group 1-14 – paper discussion 16:00-17:30 Session B: Group 15-28 – paper discussion 17:30-19:00 Lecture IV: “Dissecting neuronal circuits using chemical genetic tools” Marcelo de Oliveira Dietrich, Yale School of Medicine, USA 19:00-19:30 Break 19:30-21:00 Lecture V: " In vivo optogenetics and electrophysiology" Alexxai Kravitz, NIDDK, NIDA, USA 21:00-23:00 Dinner and Poster presentation (Room Mediterráneo) Day 3: 29/09/2015 8:30-10:30 Session A: Group 15-28 – paper discussion 11:00-13:00 Session B: Group 1-14 – paper discussion XXX REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS PROGRAM DAY 1: Tuesday September 29th 09:00-12:00 Registration 14:15 Welcome by Organizers (Room Atlantic) 14:30-15:30 Special Lecture (Room Atlantic) Chair: Joaquín Piriz, Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina " Next-generation optical technologies for cracking neural codes" Mark Schnitzer, Departments of Biological Sciences and of Applied Physics, Stanford School of Medicine, Howard Hughes Medical Institute, USA 15:30-16:00 Coffee break (Room Mediterráneo) 16:00-18:30 Symposium 1 & Symposium 2 Symposium 1 GADOR Symposium (Room Atlantic) “Technological advances to dissect neural circuits controlling behavior” Chair: M. Sol Fustiñana and M. Soledad Esposito, Friedrich Miescher Institute, Basel, Switzerland - “Temporal stability of aversive memories is determined by Lateral H abenula activity” Joaquin Piriz, Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina - “Multitasking of AGRP neurons in metabolism and behavior” Marcelo de Oliveira Dietrich, Yale School of Medicine, USA - “Spontaneous neuronal network dynamics reveals circuit' s functional adaptations for behavior” Sebastián A. Romano, Ecole Normale Supérieure, IBENS, Paris, France - “Disinhibition, a circuit mechanism for associative learning” Johannes Letzkus, Max Planck Institute for Brain Research, Frankfurt, Germany Symposium 2 (Room Topacio) “Glia at the Round Table: Microglia, Oligodendroglia and Astroglia in a Fruitful Dialogue” Chair: Juan María Pasquini, University of Buenos Aires, School of Pharmacy and Biochemistry, Argentina and Alberto Javier Ramos, Instituto de Biología Celular y Neurociencia, Prof. E. De Robertis, UBA-CONICET, Argentina - “Glia and Nervous System Energy Metabolism” Bruce Ransom, University of Washington, Seattle, USA - “Analysis of myelination and remyelination in the optic nerve” Alain Chedotal, University of Paris, France - “Atypical astrocytes are present in the ischemic lesions and contribute to the expansion of reactive gliosis" Alberto Javier Ramos, Instituto de Biología Celular y Neurociencia, Prof. E. De Robertis, UBA-CONICET, Argentina - “Mag as key player of the bi-directional communication between axons and myelin: its impact on postnatal development and disease” Pablo Lopez, Instituto de Investigación Médica Mercedes y Martín Ferreyra, CONICET, Argentina 18:45-19:30 Opening Ceremony and Tribute to Past Presidents (Room Atlantic) 19:30-20:30 Opening Lecture (Room Atlantic) Chair: Ana Belén Elgoyhen, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres, CONICET, Argentina “Emergence and mechanisms of cognition” György Buzsáki, The Neuroscience Institute, New York University School of Medicine, Ney York, USA 21:00 Welcome Reception Hotel 13 de Julio DAY 2: Wednesday September 30th 08:30-11:00 Symposium 3 & Symposium 4 Symposium 3 (Room Atlantic) “2015, The International Year of Light: Superresolution microscopies in Neuroscience” Chair: Francisco Barrantes, Instituto Investigaciones Biomédicas, UCA–CONICET, Argentina - “Nanoscopy 2.0. Converging and correlative technologies” Alberto Diaspro, Department of Nanophysics at the Istituto Italiano di Tecnologia, Genova, Italy - “Visualizing the details of neuronal polarity with fluorescence nanoscopy” Fernando Stefani, Centro de Investigaciones en Bionanociencias, Buenos Aires, Argentina - “Social organization of neurotransmitter receptor nanoclusters” Francisco Barrantes, Instituto Investigaciones Biomédicas, UCA–CONICET, Argentina - “Resolft microscopy of living cells in the nervous system" Ilaria Testa - Royal Institute of Technology, Stockholm, Sweden Symposium 4 (Room Topacio) “Translational approaches to model and treat SNC diseases ” Chair: Elena Avale and Marcelo Rubinstein, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres, CONICET, Argentina - “Levodopa induced dyskinesias: from classical pharmacology to molecular mechanisms” Oscar Gershanik, Instituto de Neurociencias de la Fundación Favaloro, Instituto de Investigaciones Farmacológicas, CONICET, Argentina - “Alzheimer’s disease, from a dish to the bed” Gorazd Bernard Stokin, St. Anne’s University Hospital, Brno, Czech Republic, Division of Neurology, University Medical Centre, Ljubljana, Slovenia - “What Can Movement Circuitry Tell Us About Obesity?” Alexxai Kravitz, NIDDK, NIDA, USA - “Phenotypic rescue in a mouse model of tauopathy using trans-splicing RNA reprogramming” Elena Avale, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres, CONICET, Argentina 11:00-11:30 Coffee break 11:30-13:15 Short Talks by students (1 & 2) Short Talks by Students 1 (Room Atlantic) Chair: Estela Maris Muñoz, Instituto de Histología y Embriología "Dr. Mario H. Burgos" and Pablo Helguera, Instituto de Investigación Médica Mercedes y Martín Ferreyra, CONICET, Argentina - “Unraveling the Role of GABAergic-Proopiomelanocortin Neurons in the H ypothalamic Control of Energy Balance” Milagros Trotta, Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina - “ASCL1 regulates late neurogenic events in the ventral neural tube” Daniela Di Bella, Fundación Instituto Leloir, Argentina - “Evaluating a possible crosstalk between inhibitory and excitatory calcium signals in inner hair cells of the developing inner ear” Marcelo Moglie, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres - “Kv1.3 is a candidate target to prevent the hypercholinergic state of parkinsonism ” Cecilia Tubert, Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina - “GDNF/GFRα1 complex is a synaptic organizer required for proper hippocampal circuit development” Dolores Irala, Instituto de Biología Celular y Neurociencia, Prof. E. De Robertis, UBA-CONICET, Argentina - “Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells ” Silvio Temprana, Fundación Instituto Leloir, Argentina - “Involvement of δCaMKII in persistent forms of memory ” Gisela Zalcman, Instituto de Fisiología, Biología Molecular y Neurociencias, CONICET, Argentina Short Talks by Students 2 (Room Topacio) Chair: Mariano Di Guilmi, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres and Nicolás Unsain, Instituto de Investigación Médica Mercedes y Martín Ferreyra, CONICET, Argentina - “Altered Corticostriatal Connectivity and Exploration- Exploitation Imbalance Emerge as Intermediate Phenotypes for a Neonatal Dopamine Dysfunction ” Bárbara Braz, Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina - “Is microglia one of the mediators of IGF-1 effects on aged rats ?” Eugenia Falomir Lockhart, Instituto de Investigaciones Bioquímicas de la Plata, CONICET, Argentina - “Altered maturation through adolescence leads to decreased hippocampal-prefrontal cortex functional connectivity in a mouse model of schizophrenia ” Rodrigo Alvarez, Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina - “Differential Reactivation Outcomes on a Single US- Contextual Fear Conditioning: a temporal prediction error account” Matías Mugnaini, Laboratorio de Psicología Experimental, Facultad de Psicología, Universidad Nacional de Córdoba - “Neurochemical phenotypes rescued in Tau Knock-out mice by human Tau re-expression ” Ana Damianich, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres, CONICET, Argentina “Aversive and appetitive memories are simultaneously formed after a single learning session in the crab Neohelice” Martín Klappenbach, Instituto de Fisiología, Biología Molecular y Neurociencias, CONICET, Argentina - “Hippocampal ERK2 differential activation after memory reconsolidation processes are modulated by α7 nicotinic acetylcholine receptors ” Maria del Carmen Krawczyk, Laboratorio de Neurofarmacología de los Porcesos de Memoria- Cátedra de Farmacología- Facultad de Farmacia y Bioquímica- UBA, Argentina 13:00-15:30 Lunch Break 15:30-16:30 Eduardo de Robertis Lecture (Room Atlantic) Chair: Cecilia Bouzat, Instituto de Investigaciones Bioquímicas Bahía Blanca, CONICET, Argentina “Opioid receptors and brain function - mouse genetic approaches” Brigitte L Kieffer, Douglas Research Center, Department of Psychiatry McGill University Montréal, Canada 16:30-19:00 Poster Session & Networking (Room Mediterráneo) 16:30-17:45 ODD NUMBER poster presentation 17:45-19:00 EVEN NUMBER poster presentation 19:00-21:00 Asamblea Anual SAN DAY 3: Thursday October 1st 08:30-11:00 Symposium 5 & Symposium 6 Symposium 5 (Room Atlantic) “Neurophysiology of conscious states” Chair: Mariano Sigman, Universidad Torcuato Di Tella and Jacobo Sitt, ICM Research Center, Pitié Salpêtrière Hospital, Paris, France - “Broadband Cortical Desynchronization Underlies the H uman Psychedelic State” Robin Carhart-Harris, University College London, England - “Large-scale brain dynamics and connectivity across different states of consciousness” Enzo Tagliazucchi, Netherlands Institute for Neuroscience, Netherlands - “Putting control back into free will” John Dylan-Haynes, Bernstein Center for Computational Neuroscience, Berlin, Germany - “Imaging neural signatures of consciousness: ‘What’, ‘When’, ‘Where’ and ‘H ow’ does it work?” Lionel Naccache, ICM Research Center, Paris, France Symposium 6 ISN Symposium (Room Topacio) “Regulation of neuronal ion channels by G protein coupled receptors” Chair: Jesica Raingo, Instituto Multidisciplinario de Biología Celular, CONICET, La Plata, Argentina. -“Neuronal calcium channels: From one to thousands” Diane Lipscombe, Brown University, Providence, USA - “Receptors coupled to Gq modulate ion channels by lipid signaling” Bertil Hille, Washington University, Seattle, USA - “Novel clustering of diverse ion channels in neurons mediated by AKAP79/150” Mark Shapiro, University of Texas Health Science Center, San Antonio, USA - “New regulation of neuronal calcium channels by G protein coupled receptors constitutive activity” Jesica Raingo, Instituto Multidisciplinario de Biología Celular, CONICET, La Plata, Argentina 11:00-11:30 Coffee break 11:30-13:00 Young Investigator Symposia 1 & 2 Young Investigator Symposium 1 (Room Atlantic) Chair: Diego Gelman, Instituto de Biología y Medicina Experimental, CONICET, Argentina - “The BDNF prodomain (pBDNF) induces neuronal morphological changes associated with neuropsychiatric and neurodegenerative diseases” Agustin Anastasia, Instituto de Investigación Médica Mercedes y Martín Ferreyra, CONICET, Argentina - “Recovery of locomotor activities in Spinal Cord Injury: A novel treatment to produce intra-axonal decrease of peroxide levels and reactivation of cytoskeleton dynamics in damaged axons” Ramiro Quintá, Instituto de Química y Fisicoquímica Biológicas, CONICET, Argentina - “A two-pronged approach against Alzheimer’s disease neurodegeneration: amyloid-beta synthesis and clearance are both regulated by glial metabotropic glutamate receptor” Daniela Durand, Instituto de Investigaciones Biomédicas, CONICET, Argentina - “Progesterone prevents chronic pain after spinal cord injury” María Florencia Coronel, Instituto de Biología y Medicina Experimental, CONICET, Argentina Young Investigator Symposium 2 (Room Topacio) Chair: Rafael Pagani, Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina - “Theta-oscillations in visual cortex emerge with experience to convey expected reward time and experienced reward rate” Camila Zold, Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina - “VTA and LC control protein synthesis required for long- term memory formation during the behavioral tagging process” Diego Moncada, Instituto de Biología Celular y Neurociencia, Prof. E. De Robertis, UBA-CONICET, Argentina - “Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing” Andres Garelli, Instituto de Investigaciones Bioquímicas Bahía Blanca, CONICET, Argentina - “Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens” Martín F. Adrover, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, USA 13:00-15:30 Lunch break 15:30-18:00 Poster Session (Room Mediterráneo) 15:30-16:45 EVEN NUMBER poster presentation 16:45-18:00 ODD NUMBER poster presentation 18:00-19:00 Ranwell Caputto Lecture (Room Atlantic) Chair: Pedro Bekinschtein, Instituto de Biología Celular y Neurociencia, Prof. E. De Robertis, UBA-CONICET, Argentina “30 years of persistence” Jorge Medina, Instituto de Biología Celular y Neurociencia, Prof. E. De Robertis, CONICET, Argentina 19:00 Award to Best Talk by Students (Sponsored by Laboratorios ELEA and ABCAM) Closing Remarks Meeting Adjourns 21:00 Finger food and Party at Tío Curzio!!!!!